Email: christopher.stewart@ncl.ac.uk

Research profile and key clinical specialties

My group researches the role of the host-microbe interaction in health and disease.

We use a range of powerful ‘omic techniques including microbe interaction to comprehensively analyse a range of clinical samples (e.g., tissue, stool, blood, swabs).

We also recently developed a model derived from human intestinal organoids that allows microbes and other stimuli to be co-cultured. Such work has wide implications for better understanding diet-microbe-host interaction, with potential to develop novel disease biomarkers and targeted therapeutic interventions to promote health across the life course.

Two key publications

• Masi AC, Embleton ND, Lamb CA, Young G, Granger CL, Najera JA, Smith DP, Hoffman KL, Petrosino JF, Bode L, Berrington JE, Stewart CJ. Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis. Gut. 2020. Online ahead of print. PMID: 33328245. DOI: 10.1136/gutjnl-2020-322771
• Stewart CJ, Ajami NJ, O’Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni D, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler AG, She J, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF. Temporal Development of the Gut Microbiome in Early Childhood from the TEDDY study. Nature. 2018; 562. 583–588. PMID: 30356187. DOI: 10.1038/s41586-018-0617-x

Possible PhD projects

• Microbiome and other ‘omic analysis of clinical samples
• Using intestinal organoid “mini-guts” to study human epithelial function

More information

I am currently a Royal Society Wellcome Trust Sir Henry Dale Fellow& Lister Institute Prize Fellow. I have a track record of obtaining Fellowships and research funding. I have also supervised numerous academic and clinical researchers.

Keywords: Gut, microbe, interaction, tissue, stool, blood, swabs, intestinal, diet, omic, Christopher, Stewart, Newcastle

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