Email: christopher.lamb@ncl.ac.uk

Research profile and key clinical specialties

I am a Consultant Gastroenterologist at the Newcastle upon Tyne Hospitals and a Principal Investigator at Newcastle University.

I have a specialist interest in Crohn’s disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD).

I am the lead author for the British guidelines for the management of IBD (see publication below).

My research focuses on precision medicine, which investigates how to choose the best drug for individual patients at the right time in their disease course.

As part of this interest I study therapeutic development and repurposing of existing treatments in the context of mucosal immunity and host-microbial interactions (a recent paper in this field is below).

A previous Wellcome Trust PhD Fellow I completed an NIHR Clinical Lecturership in 2019 after which I became a Clinical Intermediate Fellow.

I am the Chief Investigator of the national IBD-RESPONSE programme funded by the Medical Research Council (MRC) and the Helmsley Charitable Trust, a study that will build a multi-omic predictive model of responsiveness to immune modifying therapy based on the gut microbiome, metabonome and human genome.

Two key publications

• Lamb CA, Kennedy NA, Raine T, Hendy P, Smith PJ, Limdi JK, Hayee B, Lomer M, Parkes GC, Selinger CP, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop M, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson JD, Terry H, IBD guidelines eDelphi consensus group, Gaya DR, Iqbal T, Taylor SA, Smith M, Brookes MJ, Hansen R, Hawthorne AB. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut 2019;68:S1-S106
• Keir ME, Ichikawa I, Acres M, Hackney J, Hulme G, Fuh F,Carey CD, Palmer J, Jones CJ, Long AK, Mansfield JC, Kablunde S, Looney M, Filby A, Kirby JA, McBride J, Lamb CA. Regulation and role of alphaE integrin and gut homing integrins in migration and retention of intestinal lymphocytes during inflammatory bowel disease. Journal of Immunology 2021;207(9):2245-2254

Possible PhD projects

• Host immune and gut microbial mechanistic evaluation of omic-derived precision medicine targets in inflammatory bowel disease

More information

View full profiles:

• Newcastle Hospitals profile
• Newcastle University profile

Keywords: Gastroenterologist, Crohn’s, IBD, colitis, mucosal immunity, bowel, gut, microbiome, metabonome , genome, intestinal, lymphocytes, Christopher, Lamb, Newcastle

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