Email: tracy.hussell@manchester.ac.uk

Research profile and key clinical specialties

Professor Tracy Hussell is a mucosal immunologist specialising in respiratory medicine. She is Director of the Lydia Becker Institute of Immunology and Inflammation at The University of Manchester.

During her PhD at University College London she identified Helicobacter pylori as an aetiological agent in human gut lymphomas, which was published in the Lancet.

Since 1994 she has studied the molecular pathways that maintain health in the respiratory tract and how these are perturbed in acute and chronic disease including COPD, asthma and post viral infection.

She spent 19 years at Imperial College London before being recruited to director of the Manchester Collaborative Centre for Inflammation Research (MCCIR) and to date has 106 publications.

It is in this vibrant centre of 86 investigators that she has launched the careers of clinical and basic science research fellows.

The MCCIR has close translational collaborations with the University Hospital of South Manchester, Manchester Royal Infirmary and Salford Royal.

Two key publications

• Hussell T and Bell T. “Alveolar macrophages: plasticity in a tissue-specific context” Nat Rev Immunol. 2014 Feb;14(2):81-93.
• Fujimori T, Grabiec AM, Kaur M, Bell TJ, Fujino N, Cook PC, Svedberg FR, MacDonald AS, Maciewicz RA, Singh D, Hussell T. “The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung”. Mucosal Immunol. 2015 Sep;8(5):1021-30. PMID: 25603826

Possible PhD projects

• Macrophage training in the paediatric, adult and inflamed lung.
• Basal stem cell repair of the epithelial barrier.

More information

Have supervised more than 25 PhD students, with 100% submission rate. This includes clinical PhD students specialising in paediatrics, anaesthesiologist and respiratory.

Keywords: mucosal, immunology, gut, lymphomas, COPD, asthma, MCCIR, Tracey, Hussell, Manchester

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