Professor Patrick Yizhi Cai

by | 20 Jul 2022 | Manchester, Supervisors | 0 comments


Research profile and key clinical specialties

The Cai Lab has pioneered the design and construction of large synthetic chromosomes in yeast, in particular developing high throughput biotechnologies to automate the process of constructing and characterizing synthetic chromosomes.

Cai founded and co-directed the Edinburgh Genome Foundry, the world’s largest integrated synthetic biology automation facility. Cai has a strong track record in developing DNA assembly methods, which are widely used in the community to assemble large pathways in both yeast and mammalian systems.

He also developed several computational assisted design tools to facilitate the engineering biology process, ranging from construction design to whole genome engineering, and also software suites to support the UK Foundries.

Two key publications

  • Y. Shen et al. Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome. Science 355 (2017).
  • S. M. Richardson et al. Design of a synthetic yeast genome. Science 355, 1040–1044 (2017).

Possible PhD projects

  • Engineering human artificial chromosomes

More information



Keywords: chromosomes, yeast, biotechnologies, genome, Patrick, Yizhi Cai, Manchester