Email: R.El-Gendy@leeds.ac.uk

Research profile and key clinical specialties

My group focuses on all aspects of dental and skeletal tissue regeneration, including:

• characterisation of dental and mesenchymal stem cells in health and disease (diabetes, osteoarthritis, osteoporosis);
• investigating growth factors involved in dental and skeletal tissue regeneration (such as insulin growth factor axis);
• development and characterisation of alternative antimicrobial biomaterials suitable for tissue regeneration and infection control applications in dentistry and orthopaedics.

I have vast experience in multidisciplinary research with a worldwide collaborative network including clinicians, biomedical engineers, chemists, and material scientist.

Two key publications

• EL-Sayed B, Davies RPW, El-Zehery RR, Ibrahim FM, Grawish M, Kirkham J, El-Gendy R. 2020. An In-vivo Intraoral Defect Model for Assessing the Use of P11-4 Self-Assembling Peptide in Periodontal Regeneration. Frontiers in Bioengineering and Biotechnology. https://doi.org/10.3389/fbioe.2020.559494
• Alkharobi H, Alhodhodi A, Hawsawi Y, Alkafaji H, Devine D, El-Gendy R*, Beattie J*. 2016. IGFBP-2 and -3 co-ordinately regulate IGF1 induced matrix mineralisation of differentiating human dental pulp cells. Stem Cell Research. 17(3), pp. 517-522 (* co-corresponding / lead authors) https://doi.org/10.1016/j.scr.2016.09.026

Possible PhD projects

• Development and characterisation of alternative antimicrobial biomaterials for regenerative endodontics / or dental implant applications 
• Investigating the interaction between osteoarthritis and diabetes mellitus and their effect on dental and skeletal tissue regenerative therapies

More information

I lead a well-established group of PhD students and a postdoc fellow. Future students will benefit from the skills, established methods and training opportunities available in my group.

I am also the early career researchers’ champion for the Leeds School of Dentistry, organising a monthly research seminar offering updates in dental research by world leaders in the field. The research seminars are open to all postgraduate students.

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Keywords: Dental, Dentistry, Periodontal, Orthopaedics Skeletal, Tissue, Regeneration, Mesenchymal, Diabetes, Osteoarthritis, Osteoporosis, antimicrobial biomaterials, infection, Peptide, Periodontal Regeneration, Reem, El-Gendy, Leeds

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