Professor Magnus Rattray

by | 20 Jul 2022 | Manchester, Supervisors | 0 comments


Research profile and key clinical specialties

Biology has become a data-rich science. Modern high-throughput experimental techniques can make simultaneous measurements of vast numbers of biological molecules and their interactions. These measurements can be taken at different times during some biological process, resulting in time-series data.

My research group works on the interpretation of these datasets by building predictive models of biological systems using computer algorithms. We have developed methods to uncover the patterns underlying gene expression changes in time and to uncover the complex network of molecular interactions between DNA and proteins which regulate this process.

We are also interested in how biological systems change and adapt over much longer evolutionary time-scales using phylogenetic models.

Two key publications

  • Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE, Fadlullah, M. Z. H., Neo, WH., Lie-A-Ling, M., Thambyrajah, R., Patel, R., Mevel, R., Aksoy, I., Do, K. N., Savatier, P., Fontenille, L., Baker, S. M., Rattray, M., Kouskoff, V. & Lacaud, G., 15 Sep 2021, In: Blood. DOI: 1182/blood.2020007885
  • Chromatin looping links target genes with genetic risk loci for dermatological traits
    Shi, C., Ray-Jones, H., Ding, J., Duffus, K., Fu, Y., Gaddi, V., Gough, O., Hankinson, J., Martin, P., Mcgovern, A., Yarwood, A., Gaffney, P., Eyre, S., Rattray, M., Warren, R. B. & Orozco, G., 2021, In: The Journal of Investigative Dermatology. 141, 8, p. 1975-1984
    DOI: 1016/j.jid.2021.01.015



Keywords: Biology, molecules, interactions, DNA, phylogenetic models, hemogenic, endothelium, Magnus, Rattray, Manchester