Academy Fellows

Dr Adhithya Sankar

Dr Adhithya Sankar Image

Overview: I graduated from The University of Sheffield, where I completed an intercalated BMedSci research degree investigating microvascular complications in diabetes. I subsequently completed an Academic Foundation Programme in Central Manchester and soon after secured a NIHR Academic Clinical Fellowship in Diabetes and Endocrinology. During this period I gained experience in both basic science and clinical research, including working on an international multi-centre clinical study. I undertook a Masters in Medical Sciences alongside clinical training to gain additional experience in basic scientific research, which strengthened my current interest in neuroscience and neuro-endocrinology. I am currently a ST4 Trainee in the North West and have clinical responsibilities in Diabetes and Endocrinology and General Internal Medicine.

PhD title: Contribution of specific brain circuits to impaired awareness of hypoglycaemia

Brief summary of PhD project: I am interested in using both basic science and clinical research methods to investigate the pathogenesis of impaired awareness of hypoglycaemia (IAH). In this PhD I aim to establish the precise neuronal changes which underpin IAH and identify strategies for its treatment.

Supervisors:

Prof Simon Luckman (University of Manchester)

Prof Mark Dunne (University of Manchester)

Collaborations: Prof Rory McCrimmon (University of Dundee), Prof Simon Heller (University of Sheffield)

Progress so far: The first stage of my PhD has involved immunohistochemical studies aimed at establishing the distribution and function of corticotropin-releasing hormone (CRH) neurons in the mouse-brain, following physiological stressors (hypoglycaemia, cold exposure). These neurons, we hypothesise, are key to the changes which underlie IAH and thus require greater understanding. Along-side these studies, I am carrying out experiments to re-iterate the validity of our transgenic mouse model of IAH, with the assistance of collaborations with Prof McCrimmon (Dundee). In addition, I will be performing neuro-tracing experiments to investigate our proposed circuit, by delineating neuronal projections in the hypothalamus and thalamus.



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