Dr Hannah Crane
PhD Start Date: 1 September 2020
I graduated from the University of Sheffield in 2014 and my interest in research was initially sparked while undertaking a research project during an intercalated BMedSci.
I subsequently completed Dental Foundation Training and Dental Core Training and began specialist training in 2017.
I am currently a specialist trainee in Oral and Maxillofacial Pathology and have recently completed an Academic Clinical Fellowship.
During my Academic Clinical Fellowship, I developed an interest in genomic instability in Oropharyngeal Squamous Cell Carcinoma and undertook a research project exploring chemotherapy resistance funded by a Cancer Research UK (CRUK)/Pathological Society Pre-Doctoral Research Bursary.
I have also recently completed a Masters in Clinical Research at the University of Sheffield.
- Professor David Bonthron – Leeds
- Dr Ian Carr – Leeds
I am particularly interested in the molecular basis underlying treatment resistance in HPV-positive and HPV-negative Oropharyngeal Squamous Cell Carcinoma, specifically investigating the role of R-loops.
I plan to investigate this using molecular biology techniques including next-generation sequencing and DNA damage repair assays.
I hope that in the future, a combined clinical and academic role will enable me to provide the highest level of care to my patients, alongside carrying out research which aims to answer key questions regarding the mechanisms of disease.
At the end of the fellowship I intend to apply for an Academic Clinical Lectureship and seek intermediate funding which would put me in a position to apply for a Clinician Scientist Fellowship.